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Blake Watkins

Chair and Professor of Pharmaceutical Sciences

66 Results

Book(s), Monograph(s) or Book Chapter(s)

Peer-Reviewed Journal Article(s)

• "Rapid access to 3-substituted pyridines and carbolines via a domino, copper-free, palladium-catalyzed Sonogashira cross-coupling/6p-aza cyclization sequence," J. Org. Chem., 86(24), 17748-17761. (May 2021) (with Uredi, D., Burra, A. G.)
• "," Org. Chem. Front., 7, 1095-1106. (October 2020) (with Motati, D. R.; Uredi, D., Burra, A. G.; Bowen, J. P.; Fronczek, F. R.; Smith, C. R.)
• "A simple, tandem approach to the construction of pyridine derivatives under metal-free conditions: a one-step synthesis of the monoterpene natural product, (–)-actinidine.," ChemComm, 55, 3270-3273. (March 2019) (with Uredi, D., Motati, D. R.)
• "Metal-catalyzed, bidentate directing group-assisted C-H functionalization—application to the synthesis of complex natural products.," Studies in Natural Products Chemistry, in press. (March 2019) (with Motati, D. R., Uredi, Dilipkumar)
• "A General Method for the Metal-free, Regioselective, Remote C-H Halogenation of 8-Substituted Quinolines," Chem. Sci., 9, 1782-1788. (April 2018) (with Reddy, M. D. Dilipkumar, U.)
• "Design, Synthesis, and Biological Evaluation of Inhibitors of the NADPH Oxidase, Nox4.," Bioorg. Med. Chem., 26, 989-998. (April 2018) (with Xu, Q. Kulkarni, A. A. Sajith, A. M. Hussein, D. Brown, D. Güner, O. F. Reddy, D. M. Lassègue, B. Griendling, K. K. Bowen, J. P. )
• "Discovery and Therapeutic Relevance of Small-Molecule Nox4 Inhibitors.," Medicinal Chemistry Reviews, 135-150. (January 2018) (with Güner, O. F., Kulkarni, A., Lassègue, B., Griendling, K. K., and Bowen, J. P.)
• "A Unified Strategy for the Synthesis of ?-Carbolines, ?-Carbolines, and Other Fused Azaheteroaromatics under Mild, Metal-Free Conditions.," Org. Lett., 20, 6336-6339. (January 2018) (with Uredi, D., Motati, D. R.,)
• "Palladium-Catalyzed, N-(2-Aminophenyl) Acetamide-Assisted ortho-Arylation of Substituted Benzamides—Application to the Synthesis of Urolithins B, M6, and M7," J. Org. Chem., 82, 5080-5095. (January 2017) (with Reddy, M. D. Blanton, A. N.)
• "Gram-scale, Stereoselective Synthesis and Biological Evaluation of (+)-Armillariol C," J Nat. Prod., 80(9), 2561-2565. (January 2017) (with Reddy, M. D. Kobori, H. Mori, T. Wu, J. Kawagishi, H.)
• "Rh-Catalyzed, Regioselective, C H Bond Functionalization: Access to Quinoline-Branched Amines and Dimers," Organic Letters, 18, 5620-5623. (January 2016) (with Reddy, M. D. Fronczek, F. R.)
• "Design and Implementation of a Laboratory-based Drug Design and Synthesis Advanced Pharmacy Practice Experience (APPE)," American Journal of Pharmaceutical Education, 79(3), Article 43. (January 2015) (with Philip, A.; Stephens, M.; Mitchell, S. L.)
• "Palladium-catalyzed Direct Arylation of C(sp3)-H Bonds of ?-Cyano Aliphatic Amides," Journal of Organic Chemistry, 80(22), 11447-11459. (January 2015) (with Reddy, M. D.)
• "Context Dependent Activity of Solenopsin A and Analogs: Implications for Ceramide Biology," Vascular Cell, 7, 5. (January 2015) (with Karlsson, I.; Zhou, X.; Thomas, R.; Smith, A. T.; Bonner, M. Y.; Li, X.; Chen, G.; Bowen, J. P.; Qabaja, G.; Ford, S. F.; Ballard, M. D.; Petersen, K. S.; Ogretmen, B.; Zhang, J.; Arnold, R. S.; Arbiser, J. L.)
• "Recent Advances in the Development of P2Y12 Receptor Antagonists as Antiplatelet Agents.," Annual Reports in Medicinal Chemistry, 40, 87-99. (January 2014) (with Smith, A. T.)
• "," AAPS PharmSciTech. (January 2014) (with Addo, R.; Davis, K.; Ubale, R.; Owen, J. S.)
• "End of Supply Chain Screening to Assess Drug Product Quality in the U.S. Market–Omeprazole as a Case Study.," Advances in Analytical Chemistry, 3(4), 48-53. (January 2013) (with Addo, R. T; Owen, J. S.; Davis, K. R.; and Bingham, R. C.)
• "The Study of Healthcare at the Christian University," Faith and Learning: A Handbook for Christian Higher Education, 409-429. (January 2012)
• "The Future of Pharmaceutical Care," Renewing Minds, 2. (January 2012)
• "1,3-Diaxially Substituted trans-Decalins: Potential Nonsteroidal Human Progesterone Receptor Inhibitors.," JOC, 73, 7764-7767. (January 2008) (with Li, Z,; Liu, H.; Chittiboyina, A. G.; Carvalho, P. B.; Avery, M.A.)
• "Generation of Oxamic Acid Libraries: Antimalarials and Inhibitors of Plasmodium falciparum Lactate Dehydrogenase.," J. Comb. Chem., 9(2), 292-300. (January 2007) (with Choi, S. R.; Beeler, A. B.; Pradhan, A.; Rimoldi, J. M.; Tekwani, B.; Avery, M. A.)
• "Recent Developments in the Syntheses of the Epothilones and Related Analogues.," Eur. JOC, 18, 4071-4084. (January 2006) (with Chittiboyina, A. G.; Avery, M. A.)
• "The Trimethylsilyl Xylyl (TIX) Ether: A Useful Protecting Group for Alcohols.," Tetrahedron, 61(5), 1289-1295. (January 2005) (with Reddy, C. R.; Chittiboyina, A. G.; Kache, R.; Jung, J.-C.; Avery, M. A.)
• "The Epothilones and Related Analogues—A Review of Their Syntheses and Anti-Cancer Activities.," Curr. Pharm. Design, 11(13), 1615-1653. (January 2005) (with Chittiboyina, A. G.; Jung, J.-C.; Avery, M. A.)
• "Design, synthesis and evaluation of trisubstituted thiazoles targeting Plasmodium falciparum cysteine proteases.," Med. Chem. Res., 14(2, 74-105. (January 2005) (with Goud, P. M.; Sheri, A.; Desai, P. V.; Tekwani, B.; Sabnis, Y.; Gut, J.; Rosenthal, P. J.; and Avery, M. A.)
• "Synthesis and cyclization reactions of pyrazolin-5-one derivatives.," Heterocycles, 65(1), 77-94. (January 2005) (with Jung, J.C., Avery, M. A.)
• "First synthesis of antimalarial Machaeriols A and B.," Tetrahedron Lett., 45(8), 1689-1691. (January 2004) (with Chittiboyina, A. G.; Reddy, C. R.; Avery, M. A.)
• "Synthesis of 3-substituted and 3,4-disubstituted pyrazolin-5-ones.," Tetrahedron, 58(18), 3639-3646. (January 2002) (with Jung, J. C.; Avery, M. A.)
• "Toward the total synthesis of pseudolaric acid B. Preparation of a key intermediate by degradation and its use in the reassembly of the natural product.," Tetrahedron Lett., 43(22), 4095-4098. (January 2002) (with Wu, B.; Karle, J. M.; Avery, M. A.)
• "Efficient synthesis of 3-substituted pyrazolin-5-ones.," Synth. Commun., 32(24), 3767-3777. (January 2002) (with Jung, J. C.; Avery, M. A.)
• "Inhibition of Tyrosine Phenol-lyase from Citrobacter freundii by 2-azatyrosine and 3-azatyrosine.," Biochemistry, 40(49), 14862-14868. (January 2001) (with Phillips, R. S.)
• "Enzymatic synthesis of azatyrosines.," Bioorg. Med. Chem. Lett., 11(16), 2099-2100. (January 2001) (with Phillips, R. S.)

Presentation(s)

• "Progress Towards Structure-based De Novo Design and Synthesis of Small Molecule Inhibitors of Protective Antigen (PA): An Anti-toxin Approach for Combating Anthrax." (with Jones, K.; Castleman, A.; Phillip, A.)
  251st American Chemical Society Meeting, San Diego, CA. (March 2016)
• "Palladium-catalyzed Direct Arylation of C(sp3)-H Bonds of ?-Cyano Aliphatic Amides." (with Reddy, M. D.)
  Joint Southeast/Southwest Regional Meeting of the American Chemical Society, Memphis, TN. (November 2015)
• "A Virtual Screening Protocol to Identify Potential Small Molecule Inhibitors of PknG." (with Castleman, A., Mohan, D., Hunter, N., Philip, A.)
  42nd Annual MALTO Medicinal Chemistry and Pharmacognosy Meeting in Miniature., Oxford, MS. (May 2015)
• "Development and Validation of a UPLC Method for Rapid and Simultaneous Analysis of Proton Pump Inhibitors." (with Addo, R.; Davis, K.; Ubale, R.; Owen, J.)
  American Association of Pharmaceutical Scientists Annual Meeting and Exposition, San Diego, CA. (November 2014)
• "Assessment of Faculty Perceptions of Promotion." (with Goad, Jeff; Helms, Kristen; Jones, Jocelyn; Kahaleh, Abby; Knoderer, Chad; Rospond, Raylene.)
  2014 Midwest Social and Administrative Pharmacy Conference, Purdue University, West Lafayette, IN. (July 2014)
• "Assessment of Faculty Perceptions of Promotion." (with Goad, Jeff; Helms, Kristen; Jones, Jocelyn; Kahaleh, Abby; Knoderer, Chad; Rospond, Raylene.)
  2014 American Association of Colleges of Pharmacy (AACP) Annual Meeting, Grapevine, TX. (July 2014)
• "Virtual screening for potential small molecule inhibitors of protein kinase G: a promising target for multidrug resistant tuberculosis." (with Mohan, Devipriya; Hunter, Neil; Nguyen, Dan; Philip, Ashok)
  Union University Fall Poster Session, Jackson, TN. (November 2013)
• "Innovations in Education: Design and Implementation of a Laboratory-Based Drug Design and Synthesis APPE." (with Philip, Ashok E.; Stephens, Mark A.; Mitchell, Sheila)
  AACP Annual Meeting, Pharmacy Education, Chicago, IL. (July 2013)
• "Innovations in Education: Design and Implementation of a Laboratory-Based Drug Design and Synthesis APPE." (with Philip, Ashok E.; Stephens, Mark A.; Mitchell, Sheila)
  AACP Annual Meeting, Round-table Discussion, Pharmacy Education, Chicago, IL. (July 2013)
• "Alzheimer’s Disease: Understanding the Future of Drug Discovery." Invited talk, Alzheimer’s Disease Caregivers Support Group, West Tennessee Healthcare/JMCGH, Jackson, TN. (June 2013)
• "Novel Synthesis and Activity of Solenopsin A and Analogs, Topical Inhibitors of Phosphoinositol-3 Kinase/Akt with Ceramide-like Properties." (with Karlsson, I.; Bonner, M. Y.; Zhou, X.; Zhang, J.; Bowen, JP; and Arbiser, J. L.)
  International Investigative Dermatology Conference, Edinburg, Scotland, . (May 2013)
• "Pseudolaric Acid B (PLAB): A Novel Antifungal/Anticancer Natural Product." Invited talk, Mercer University College of Pharmacy and Health Sciences, Macon, GA. (March 2013)
• "Clickers in the Classroom: Keeping Students Engaged." uTech Expo 2013, Union University, Jackson, TN. (March 2013)
• "Advanced Tips and Tricks for ANY Rotary Evaporator" (with Reid, J.)
  Webinar, American Pharmaceutical Review. (February 2013)
• "Progress towards structure-based de novo design and synthesis of small molecule inhibitors of protective antigen (PA): an anti-toxin approach for combating anthrax." (with Shah, S., Hunter, N.; Mohan, D.; Philip, A.)
  Annual Union University Scholarship Symposium, Jackson, TN. (November 2012)
• "Structure-Based De Novo Design and Synthesis of Protein-Protein Interaction Inhibitors: A Novel Anti-Toxin Approach for Combating Anthrax." (with Blanton, A; Philip, A.)
  Honors Research Symposium, Mississippi University for Women, Columbus, MS. (November 2012)
• "Solution-phase parallel synthesis of small molecule inhibitors of protective antigen (PA): a novel anti-toxin approach for combating anthrax." (with Hise, N. W. V.; Mitchell, J.; Hunter, N.; Mohan, D.; Philip, A.)
  Tennessee Pharmacists Association, Nashville, TN. (February 2012)
• "Progress Towards the Total Synthesis of Crotogoudin: A Potent Cytotoxic 3,4-seco-atisane from Croton goudotii." (with Smith, A. T.; Pierce, B. A.; Philip, A.)
  Union University Scholarship Symposium, Jackson, TN. (May 2011)
• "Solution-phase parallel synthesis of small molecule inhibitors of protective antigen (PA): a novel anti-toxin approach for combating anthrax." (with Hise, N. W. V.; Mitchell, J.; Hunter, N.; Mohan, D.; Philip, A.)
  Union University Scholarship Symposium, Jackson, TN. (May 2011)
• "Structure-based de novo design of small molecule inhibitors of protective antigen (PA): a novel anti-toxin approach for combating anthrax." (with Hunter, N.; Mohan, D.; Mitchell, J.; Hise, N. W. V.; Philip, A.)
  8th Annual Union University Scholarship Symposium, Jackson, TN. (May 2011)
• "Evaluation of Potential Determinants of Successful Performance in First Year Pharmacy Students." (with DeMaagd, G., Owen, J., King, S., Jones, K., Stephens, M., Kuhl, D., Martin, A., Mitchell, S., Clarke, J.)
  AACP Annual Meeting, Seattle, WA. (July 2010)
• "Progress towards the total synthesis of pseudolaric acid B: a novel antipneumocystic and antifungal natural product." (with Vines, K. K.; Avery, M. A.; Feller, D. R.)
  228th National Meeting of the American Chemical Society, Philadelphia, PA. (January 2004)
• "Progress towards the total synthesis of pseudolaric acid B, a novel antipneumocystic and antifungal natural product from Pseudolarix kaempferi." (with Avery, M. A.; Vines, K. K.; Weldon, D.; Feller, D. R.)
  55th Southeast Regional Meeting of the American Chemical Society, Plenary presentation, Atlanta, GA. (January 2003)

Award/Recognition(s)

• Patent - NADPH Oxidase Inhibitors and Uses Thereof US Patent Number 11236053, Guner, O; Lassegue, B.; Griendling, K.; Xu, Q.; Brown, D.; Bowen, J.P.; Kulkarni, A., 2022
• Patent - Novel Methods for Preparation of Substituted Pyridines and Related Novel Compounds US Patent Number 11117893, Uredi, D.; Motati, D. R., 2021
• Patent Application - Novel Methods for Preparation of Substituted Pyridines and Related Novel Compounds Application US17/467,413, Uredi, D.; Motati, D. R., 2021
• Patent - NADPH Oxidase Inhibitors Application 62/537,267, 2017
• Patent - Solenopsin and Derivatives, Therapeutic Compositions, and Methods Related Thereto. U.S. Patent Number 9592226, 2017
• Patent Application - Novel 1,2-Diarylethanone NOX inhibitors. U.S. Provisional Patent Application 62010670, filed June 11, 2014, 2014
• Patent Application - Small Molecule Inhibitors of NADPH Oxidase U.S. Provisional Patent Application 62011230, file June 12, 2014, 2014
• Faculty Member of the Year 2014
• Patent Pending - Solenopsin and Derivatives, Therapeutic Compositions, and Methods Related Thereto. U.S. Patent Application 14/271,982, filed May 8, 2014, patent pending, 2014
• Granted Tenure 2014
• Member of AACP 2013-14 Academic Leadership Fellows Program cohort class 2013